Recovery After Initial Schizophrenia Episode:

Early Treatment Program



NIMH Contract


7/13/09 – 7/12/14

Contact: Kim Mueser


Recovery After an Initial Schizophrenia Episode (RAISE) is an NIMH research project that seeks to fundamentally change the trajectory and prognosis of schizophrenia through coordinated and aggressive treatment in the earliest stages of illness. RAISE is designed to reduce the likelihood of long-term disability that people with schizophrenia often experience. It aims to help people with the disorder lead productive, independent lives. At the same time, it aims to reduce the financial impact on the public systems often tapped to pay for the care of people with schizophrenia.

NIMH has awarded separate contracts to two independent research teams to develop interventions that can be tested in real-world treatment settings and be readily adopted and quickly put into practice should they prove successful. The contract awards, bolstered by funds from the American Recovery and Reinvestment Act of 2009, have been awarded to: the Feinstein Institute for Medical Research (Principal Investigator, John M. Kane, M.D.) in Manhasset, NY, and to the Research Foundation for Mental Hygiene at Columbia University (Principal Investigator, Lisa Dixon M.D.) in New York City.(1)

The team led by Dr. Kane has developed the RAISE Early Treatment Program, a research study which is being conducted in community clinics across the United States. This study is comparing the “Navigate” model for community-based treatment for people with first episode psychosis with customary care. Navigate uses a team-based approach to provide people with individualized psychopharmacology, individual resiliency training, family psychoeducation, and supported employment and/or education. A total of 35 sites in 21 states (including over 400 individuals) are participating in the study, with sites randomly assigned to provide either the Navigate program or customary services for a minimum of 2 years. Routine assessments are conducted for at least 2 years to evaluate outcomes across a range of different domains, including symptoms, hospitalizations, school and work functioning, and quality of life.

1 Recovery After an Initial Schizophrenia Episode (RAISE): A Research Project of the NIMH


Boston University Center for Psychiatric Rehabilitation Staff Role
Kim T. Meuser, Ph.D. Co-Investigator
Jennifer Gottlieb, Ph.D. Co-Investigator
Susan Gingerich, M.S.W., Independent Consultant Co-Investigator
Feinstein Institute, NY Staff Role
John M. Kane, M.D. Principal Investigator
Christof Correll, M.D. Co-Investigator
Delbert G. Robinson, M.D. Co-Investigator
Patricia Marcy, B.S.N. Project Coordinator
Dartmouth Medical School, NH Staff Role
Mary F. Brunette, M.D. Co-Investigator
David Lynde, M.S.W. Co-Investigator
Harvard University, MA Staff Role
Corinne Cather, Ph.D. Co-Investigator
Nathan Kilen Institute, NY Staff Role
James Robinson, M.Ed. Co-Investigator
Connie Klein, Ph.D. Co-Investigator
University of Calgary, Canada Staff Role
Jean Addington, Ph.D. Co-Investigator
University of California at Los Angeles, CA Staff Role
Shirley M. Glynn, Ph. D. Co-Investigator
University of North Carolina, Chapel Hill Staff Role
David L. Penn, Ph.D. Co-Investigator
Sue E. Estroff, Ph.D. Co-Investigator
Piper Meyer, Ph.D. Co-Investigator
Sylvia Saade, L.C.S.W., Ph.D. Project Coordinator
Yale University, CT Staff Role
Robert Rosenheck, M.D., Ph.D. Co-Investigator


No documents are available at this time. Please use the project contact for specific inquiries.


Inquiries related to the project should be addressed to:

Kim Mueser
Boston University, Center for Psychiatric Rehabilitation
940 Commonwealth Avenue West, 2nd Floor
Boston, MA 02215